Resilience

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country
1 finding against

Funder: National Institute on Aging

Humans2

Outcomes

Subjective cognitive decline

no changein humans1

1 study

Resilience has no effect on subjective cognitive decline in humans (β = -0.081, p = <0.326).
“higher resilience is significantly associated with lower SCD scores in Black women (β = ‐0.186, p = <0.002) but not in men (β = ‐0.081, p = <0.326).”
Humansmales
Gender Differences in the Effect of Grit and Resilience on Subjective Cognitive Decline Amongst Black Americans
AAIC 2025 abstract26 Dec 2025

Associations

Subjective cognitive decline

downin humans2

2 studies

Resilience predicts subjective cognitive decline in humans (β = -0.234, p = .007).
“higher resilience predicting lower SCD scores (β = -0.234, p = .007)”
Humansfemales
Effect of Non-Cognitive Traits on Subjective Cognitive Decline among Black American adults
GSA 2025 abstract31 Dec 2025
Resilience is associated with subjective cognitive decline in humans (β = -0.186, p = <0.002).
“higher resilience is significantly associated with lower SCD scores in Black women (β = ‐0.186, p = <0.002) but not in men”
Humansfemales
Gender Differences in the Effect of Grit and Resilience on Subjective Cognitive Decline Amongst Black Americans
AAIC 2025 abstract26 Dec 2025