Psychotropic medications

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funder: Japan Society for the Promotion of Science

Human trial1
Humans1

Outcomes

Food Intake LEVEL Scale

no changein humans1

1 study

Psychotropic medications have no effect on Food Intake LEVEL Scale in humans (p = 0.970).
“The association was consistent in both sensitivity analyses (Model 1: B = -0.386, p = 0.019; Model 2: B = -0.345, p = 0.020), but not FILS score at discharge (p = 0.970).”
Humansolder inpatients at dischargen = 202
Association between psychotropic medication use and declines in activities of daily living in previously independent older inpatients: a prospective cohort study
Annals of geriatric medicine and research3 Sep 2026

Associations

Katz index

downin humans1

1 study

Psychotropic medications are associated with Katz index in humans (B = -0.333, p = 0.046).
“psychotropic use was independently associated with a lower discharge Katz Index (B = -0.333, p = 0.046).”
Humansolder inpatients independent of ADL before admissionn = 202
Association between psychotropic medication use and declines in activities of daily living in previously independent older inpatients: a prospective cohort study
Annals of geriatric medicine and research3 Sep 2026