PRS-CARV
Intervention1 paper1 finding
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.
Funders: Case Western Reserve University and others
- Humans1
Outcomes
1Prediction of lipid traits
upin humans1
1 study
Prediction of lipid traits
upin humans1
PRS-CARV improves prediction of lipid traits in humans (2–11%).
Humanswhole-genome sequencing data
PRS-CARV: A summary statistics framework for integrating annotation-informed rare variants to improve polygenic risk prediction · Research Square · 31 Aug 2026 · Preprint