Protocol standardization

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Humans2

Outcomes

3

Mean diffusivity

no changein humans1

1 study

Protocol standardization has no effect on mean diffusivity in humans.
“GCC‐FA and GCC‐MD showing no significant differences”
Humansin two-site ongoing MCSA cohortcorpus callosum
Diffusion MRI protocol standardization reduces measurement variability in the longitudinal Mayo Clinic Study of Aging
AAIC 2025 abstract25 Dec 2025

More on Mean diffusivity

Fractional anisotropy

no changein humans1

1 study

Protocol standardization has no effect on fractional anisotropy in humans.
“For the ongoing MCSA data from two sites, MD and FA whole‐brain densities were more closely aligned, with GCC‐FA and GCC‐MD showing no significant differences”
Humansin two-site ongoing MCSA cohortcorpus callosum
Diffusion MRI protocol standardization reduces measurement variability in the longitudinal Mayo Clinic Study of Aging
AAIC 2025 abstract25 Dec 2025

More on Fractional anisotropy

dMRI metrics differences

downin humans1

1 study

Protocol standardization decreases dMRI metrics differences in humans.
“Differences in dMRI metrics seen when comparing across unstandardized protocols were reduced when protocols were standardized.”
Humansin standardized protocols from ongoing MCSA across two sites
Diffusion MRI protocol standardization reduces measurement variability in the longitudinal Mayo Clinic Study of Aging
AAIC 2025 abstract23 Dec 2025

More on dMRI metrics differences

Latest

2 in 12 months

AAIC 2025 Abstract25 Dec

Diffusion MRI protocol standardization reduces measurement variability in the longitudinal Mayo Clinic Study of Aging

Cohort study in peopleBiomarkers

AAIC 2025 Abstract23 Dec

Diffusion MRI protocol standardization reduces measurement variability in the longitudinal Mayo Clinic Study of Aging

Cohort study in peopleBiomarkers