Pipecolic acid + succinate
Intervention1 paper6 findingsPubChem 849PubChem 160419ChEBI 17964ChEBI 30031
- Animals1
Outcomes
6Citrate synthase activity
upin mice1Very low certainty
1 study
Citrate synthase activity
upin mice1Very low certainty
Pipecolic acid + succinate increases citrate synthase activity in mice.
Animalsunilateral hindlimb casting; increased in females but not malesgastrocnemius10 days
Microbial compounds limited muscle loss in aged mice · Physiological reports · 1 Oct 2026
Soleus fatigue resistance
upin mice1Very low certainty
1 study
Soleus fatigue resistance
upin mice1Very low certainty
Pipecolic acid + succinate improves soleus fatigue resistance in mice.
Animalsunilateral hindlimb castingsoleus10 daysmales
Microbial compounds limited muscle loss in aged mice · Physiological reports · 1 Oct 2026
Soleus absolute force and rate of force development
upin mice1Very low certainty
1 study
Soleus absolute force and rate of force development
upin mice1Very low certainty
Pipecolic acid + succinate increases soleus absolute force and rate of force development in mice.
Animalsunilateral hindlimb castingsoleus10 daysfemales
Microbial compounds limited muscle loss in aged mice · Physiological reports · 1 Oct 2026
Muscle fiber cross-sectional area
downin mice1Very low certainty
1 study
Muscle fiber cross-sectional area
downin mice1Very low certainty
Pipecolic acid + succinate protects against muscle fiber cross-sectional area in mice.
Animalsunilateral hindlimb castingsoleus and plantaris10 daysboth; largest effect in female soleuss
Microbial compounds limited muscle loss in aged mice · Physiological reports · 1 Oct 2026
Soleus and plantaris mass
no changein mice1Very low certainty
1 study
Soleus and plantaris mass
no changein mice1Very low certainty
Pipecolic acid + succinate has no effect on soleus and plantaris mass in mice.
Animalsunilateral hindlimb castingsoleus and plantaris10 days
Microbial compounds limited muscle loss in aged mice · Physiological reports · 1 Oct 2026
Gastrocnemius mass
upin mice1Very low certainty
1 study
Gastrocnemius mass
upin mice1Very low certainty
Pipecolic acid + succinate increases gastrocnemius mass in mice.
Animalsunilateral hindlimb casting; compared with vehiclegastrocnemius10 days
Microbial compounds limited muscle loss in aged mice · Physiological reports · 1 Oct 2026
Latest
1Microbial compounds limited muscle loss in aged mice
In a 10-day experiment, two compounds improved different aspects of muscle function in aged male and female mice with one hindlimb immobilised.In a 10-day experiment, two compounds improved different aspects of muscle function in aged male and female mice with one hindlimb immobilised.