Pinealectomy

1. Pinealectomy induces astrogliosis in rats.

   “Conversely, astrogliosis was observed in young adult and middle-aged groups with melatonin deficiency in certain regions of the dHipp.”

   Animalsmelatonin deficiency; effects in certain regionsdorsal hippocampus

   Pinealectomy-Induced Neuroinflammation Varies with Age in Rats

   International journal of molecular sciences·21 Aug 2025

1. Pinealectomy induces microgliosis in rats.

   “Pinealectomy triggered microgliosis in both young and old rats, but middle-aged rats were resistant to microglia activation.”

   Animalsinduced in young and old rats; middle-aged rats resistantdorsal hippocampus

   Pinealectomy-Induced Neuroinflammation Varies with Age in Rats

   International journal of molecular sciences·21 Aug 2025

1. Pinealectomy increases neuronal NF-κB expression in rats.

   “Removal of the pineal gland resulted in significant, region-specific increases in NF-kB expression in neurons of the dHipp in the youngest and middle-aged groups.”

   Animalsregion-specific effectsdorsal hippocampus

   Pinealectomy-Induced Neuroinflammation Varies with Age in Rats

   International journal of molecular sciences·21 Aug 2025

More on Neuronal NF-κB expression

1. Pinealectomy is associated with neuronal pAkt1 expression in rats.

   “the change in expression of the phosphorylated form of Akt (pAkt1) in neurons went in the opposite direction in these two age groups”

   Animalsage-dependent and region-dependent changesdorsal hippocampus

   Pinealectomy-Induced Neuroinflammation Varies with Age in Rats

   International journal of molecular sciences·21 Aug 2025

More on Neuronal pAkt1 expression