Pfna
Pfna has been studied in 4 papers since 2016: 2 trials and 1 observational study in people, 1 review. The newest paper, Oct 25, 2017: “Meta-analysis of the efficacy and safety of PFNA and InterTAN for the treatment of intertrochanteric fractures”.
4 papers study it7 findingsUpdated
“The pain VAS score decreased from preoperative 7.70±1.97 to 1.00±0.26 at 6 months after operation(P<0.01).”
None of its findings points the other way.
- 3 independent labs in 3 countries
- Human trial2
- Humans1
Studies in people
1 study gave pfna to people and measured what changed.
down: Decreases hip painVAS score 7.70±1.97 preoperatively versus 1.00±0.26 at 6 months
up: Improves hip functionHarris hip score 8.70±4.19 preoperatively versus 91.70±5.31 at 6 months
Treated cohort49 peopleBoth65–91 years; mean 79 years6 months
Older adults; The oldest old; femoral intertrochanteric fracture
Zhongguo gu shang = China journal of orthopaedics and traumatology, Oct 25, 2017
What did studies of Pfna find?
5Studies of Pfna measured 5 outcomes; the most studied are hip function (1 study), hip pain (1) and internal fixation complication rate (1).
Hip function
upin humans1
1 study
Hip function
upin humans1
Pfna improves hip function in humans (Harris hip score 8.70±4.19 preoperatively versus 91.70±5.31 at 6 months).
“Harris hip score improved from preoperative 8.70±4.19 to 91.70±5.31 at 6 months after operation(P<0.01).”
Human trialfemoral intertrochanteric fracture; compared with preoperative scoreship6 months41 males and 8 femalessn = 49
Zhongguo gu shang = China journal of orthopaedics and traumatology
Hip pain
downin humans1
1 study
Hip pain
downin humans1
Pfna decreases hip pain in humans (VAS score 7.70±1.97 preoperatively versus 1.00±0.26 at 6 months).
“The pain VAS score decreased from preoperative 7.70±1.97 to 1.00±0.26 at 6 months after operation(P<0.01).”
Human trialfemoral intertrochanteric fracture; compared with preoperative scoreship6 months41 males and 8 femalessn = 49
Zhongguo gu shang = China journal of orthopaedics and traumatology
Internal fixation complication rate
upin humans1
1 study
Internal fixation complication rate
upin humans1
Pfna increases internal fixation complication rate in humans (Reported as MD 4.17, 95% CI 1.33 to 13.08).
“The complications of PFNA are more than those of InterTAN.”
ReviewCompared with InterTAN for femoral intertrochanteric fracture
Zhongguo gu shang = China journal of orthopaedics and traumatology
Operative time
downin humans1
1 study
Operative time
downin humans1
Pfna decreases operative time in humans (MD -25.75, 95% CI -37.47 to -14.03; units not stated).
“The operation time of PFNA is shorter than that of InterTAN, and there is less blood loss during operation.”
ReviewCompared with InterTAN for femoral intertrochanteric fracture
Zhongguo gu shang = China journal of orthopaedics and traumatology
Harris hip score
no changein humans1
1 study
Harris hip score
no changein humans1
Pfna has no effect on harris hip score in humans (MD -1.00, 95% CI -2.29 to 0.28).
“The meta-analyses showed no significant differences between the two methods on Harris scores[MD=-1.00, 95%CI(-2.29, 0.28), P=0.13]”
ReviewCompared with InterTAN for femoral intertrochanteric fracture
Zhongguo gu shang = China journal of orthopaedics and traumatology
What is Pfna linked with?
2Studies link Pfna with 2 measures, most often mobility (1 study) and fracture healing (1).
Mobility
mixedin humans1
1 study
Mobility
mixedin humans1
Pfna is associated with mobility in humans (Approximately 60% regained pretrauma mobility).
“Approximately 60 % of patients achieved the mobility level prior to trauma.”
Humanstrochanteric fragility fractures
Operative Orthopadie und Traumatologie
Fracture healing
upin humans1
1 study
Fracture healing
upin humans1
Pfna is associated with fracture healing in humans (All fractures healed after an average of 15.3 months).
“Of the 72 patients available for follow-up (average age 85.3 years), all fractures healed after an average of 15.3 months.”
Humanstrochanteric fragility fracturesproximal femuraverage of 15.3 monthsn = 72
Operative Orthopadie und Traumatologie