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Ovariohysterectomy

Exposure

3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Gouvernement du Canada | Canadian Institutes of Health Research and 2 more

What did studies of Ovariohysterectomy find?

3

Studies of Ovariohysterectomy measured 3 outcomes; the most studied are cyclic creep strain (1 study), PRG4 (1) and ligament modulus (1).

Cyclic creep strain

upin O. cuniculus1

1 study

  1. Ovariohysterectomy increases cyclic creep strain in O. cuniculus.

    “Adolescent OVH MCLs exhibited increased cyclic, static and total creep strain with decreased mRNA levels for the progesterone receptor.”

    Animalsin adolescent rabbitsmedial collateral ligamentfemales

    Increased lubricin/proteoglycan 4 gene expression and decreased modulus in medial collateral ligaments following ovariohysterectomy in the adult rabbit: Evidence consistent with aging

    Journal of biomechanics

More on Cyclic creep strain

PRG4

upin O. cuniculus1

1 study

  1. Ovariohysterectomy increases PRG4 in O. cuniculus.

    “Adult OVH MCLs exhibited increased cyclic creep and failure strain, and decreased modulus with increased mRNA levels for lubricin/PRG4 and collagen I compared with normal MCLs.”

    Animalsin adult rabbits compared with normal MCLsmedial collateral ligamentfemales

    Increased lubricin/proteoglycan 4 gene expression and decreased modulus in medial collateral ligaments following ovariohysterectomy in the adult rabbit: Evidence consistent with aging

    Journal of biomechanics

More on PRG4

Ligament modulus

downin O. cuniculus1

1 study

  1. Ovariohysterectomy decreases ligament modulus in O. cuniculus.

    “Adult OVH MCLs exhibited increased cyclic creep and failure strain, and decreased modulus with increased mRNA levels for lubricin/PRG4 and collagen I compared with normal MCLs.”

    Animalsin adult rabbits compared with normal MCLsmedial collateral ligamentfemales

    Increased lubricin/proteoglycan 4 gene expression and decreased modulus in medial collateral ligaments following ovariohysterectomy in the adult rabbit: Evidence consistent with aging

    Journal of biomechanics

More on Ligament modulus