Orsay virus infection

1. Orsay virus infection has no effect on biological age in worms.

   “where the nonpathogenic Orsay virus produced negligible aging acceleration.”

   Model organismsnonpathogenic infection

   Enteric viral infections promote systemic accelerated aging in Drosophila

   Science advances·5 Jun 2026

More on Biological age

1. Orsay virus infection impairs piRNA, rRNA and tsRNA regulation in worms.

   “Superinfection, in turn, had little impact on the overall transcriptome, but showed a misregulation of piRNAs, rRNAs, and tsRNAs.”

   Model organismsSuperinfection

   Chronic infection of Caenorhabditis elegans by Orsay virus induces age-dependent immunity and superinfection exclusion

   bioRxiv (Cold Spring Harbor Laboratory)·26 Dec 2024Preprint

1. Orsay virus infection induces transcriptomic and small RNA alterations in worms.

   “Primary infections produced transcriptomic and small RNA alterations”

   Model organismsPrimary infection; extent depended on developmental stage at infection and time until sampling

   Chronic infection of Caenorhabditis elegans by Orsay virus induces age-dependent immunity and superinfection exclusion

   bioRxiv (Cold Spring Harbor Laboratory)·26 Dec 2024Preprint

1. Orsay virus infection decreases viral replication upon subsequent inoculation in worms.

   “animals that have been previously exposed to the virus are able to control viral replication upon a subsequent inoculation, indicative of superinfection exclusion.”

   Model organismsPreviously exposed animals; protection against various Orsay virus isolates

   Chronic infection of Caenorhabditis elegans by Orsay virus induces age-dependent immunity and superinfection exclusion

   bioRxiv (Cold Spring Harbor Laboratory)·26 Dec 2024Preprint