Ornithine alpha-ketoglutarate
Ornithine alpha-ketoglutarate has been studied in 4 papers since 1995: none in people yet, 1 in animals, 1 in cells, 2 reviews. The research so far is in animals and cells. The newest paper, Nov 30, 2016: “Nutritional supplementation for hip fracture aftercare in older people”.
See all 5 papers on ornithine alpha-ketoglutarate
At a glance
The findings reach mice, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Animals1
- Cells1
What did studies of ornithine alpha-ketoglutarate find?
5Studies of ornithine alpha-ketoglutarate measured 5 outcomes, among them muscle loss, Insulin and growth hormone secretion and plasma and muscle glutamine pools.
Muscle loss
downin reviews1
1 study
Muscle loss
downin reviews1
Ornithine alpha-ketoglutarate decreases muscle loss in several pathological conditions associated with muscle loss.
“A beneficial anabolic action of OKG has been demonstrate in several pathological conditions associated with muscle loss.”
Reviewin several pathological conditions associated with muscle loss
Ornithine alpha-ketoglutarate: could it be a new therapeutic option for sarcopenia?
The journal of nutrition, health & aging
Insulin and growth hormone secretion
upin reviews1
1 study
Insulin and growth hormone secretion
upin reviews1
Ornithine alpha-ketoglutarate increases insulin and growth hormone secretion.
“increases the secretion of anabolic hormones, i.e. insulin and growth hormone”
Review
Ornithine alpha-ketoglutarate: could it be a new therapeutic option for sarcopenia?
The journal of nutrition, health & aging
Plasma and muscle glutamine pools
upin rats1
1 study
Plasma and muscle glutamine pools
upin rats1
Ornithine alpha-ketoglutarate increases plasma and muscle glutamine pools in rats (relative to ornithine or alpha-ketoglutarate alone in burn injury) (plasma Gln versus alpha-KG p<0.01 and versus Orn p<0.01; muscle Gln versus alpha-KG p<0.01 and versus Orn p<0.05).
“OKG was more efficient than Orn or alphaKG alone in restoring Gln pools in plasma and muscle, which is evidence of metabolic interaction between the two components of this molecule.”
Animalsrelative to ornithine or alpha-ketoglutarate alone in burn injuryplasma and skeletal muscle5 g/kg day48 hn = 48
Intensive care medicine
Plasma glutamine
upin rats1
1 study
Plasma glutamine
upin rats1
Ornithine alpha-ketoglutarate increases plasma glutamine in rats (burn injury with enteral refeeding, compared with glycine control) (significantly higher than control, p<0.01).
“In OKG-treated animals, plasma Gln as well as muscle Glu and Gln were significantly higher than in the control (p<0.01)”
Animalsburn injury with enteral refeeding, compared with glycine controlplasma5 g/kg day48 hn = 48
Intensive care medicine
Hepatic proline content
upin rats1
1 study
Hepatic proline content
upin rats1
Ornithine alpha-ketoglutarate increases hepatic proline content in rats (when associated with ornithine as OKG).
“it led to an increase in glutamate release and in proline content in the liver”
Animalswhen associated with ornithine as OKGsalt of ornithine and alpha-ketoglutarateliver1 hn = 6
Metabolism of ornithine, alpha-ketoglutarate and arginine in isolated perfused rat liver
The British journal of nutrition