Olpasiran, lepodisiran, and zerlasiran

Intervention1 paper1 finding

Outcomes

1

Lipoprotein

downin humans1Low certainty

1 study
  1. Olpasiran, lepodisiran, and zerlasiran decreases lipoprotein in humans (Reductions of up to 80% to 95%).

    ReviewSeparate siRNA-based therapies, not a combination treatmentsmall interfering RNA

    Efficacy and tolerability of targeted lipoprotein(a)-lowering therapies: A systematic review · Journal of clinical lipidology · 26 Aug 2026

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