Olpasiran, lepodisiran, and zerlasiran
Intervention1 paper1 finding
Outcomes
1Lipoprotein
downin humans1Low certainty
1 study
Lipoprotein
downin humans1Low certainty
Olpasiran, lepodisiran, and zerlasiran decreases lipoprotein in humans (Reductions of up to 80% to 95%).
ReviewSeparate siRNA-based therapies, not a combination treatmentsmall interfering RNA
Efficacy and tolerability of targeted lipoprotein(a)-lowering therapies: A systematic review · Journal of clinical lipidology · 26 Aug 2026
Latest
1Journal of Clinical LipidologyReview