Normobaric hypoxia

Intervention

1 paper3 findings

  • 1 lab
  • Human trial1

Outcomes

3

Working memory

downin humans1

1 study
  1. Normobaric hypoxia impairs working memory in humans.

    “N2-back declined only at 12.5% FiO2 (p = 0.014), and OST worsened from 14.5% FiO2 onward (p < 0.001).”

    Human trialhigh working memory load (OST and 2-back)35-55 min

    Graded normobaric hypoxia alters cerebral oxygenation and cognition in middle-aged adults: a single-blind counterbalanced randomized crossover trial

    GeroScience9 Mar 2026

Cognitive function

downin humans1

1 study
  1. Normobaric hypoxia impairs cognitive function in humans.

    “from 14.5% FiO2, reaction time slowed (p < 0.001), and accuracy declined on the flexibility task (p < 0.001).”

    Human trialFiO2 14.5% and 12.5%35-55 min

    Graded normobaric hypoxia alters cerebral oxygenation and cognition in middle-aged adults: a single-blind counterbalanced randomized crossover trial

    GeroScience9 Mar 2026

Cerebral oxygenation

downin humans1

1 study
  1. Normobaric hypoxia decreases cerebral oxygenation in humans.

    “ΔHbO2 fell progressively (p = 0.002), while ΔHHb increased only at 12.5% FiO2 (p = 0.011)”

    Human trial35-55 min

    Graded normobaric hypoxia alters cerebral oxygenation and cognition in middle-aged adults: a single-blind counterbalanced randomized crossover trial

    GeroScience9 Mar 2026

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