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Non-ablative fractional laser 1940-nm treatment

Non-ablative fractional laser 1940-nm treatment has been studied in 1 paper since 2026: 1 trial in people; 1 in the past year. The newest story, Oct 30, 2026: “Laser treatment shifted aging-linked DNA marks in human skin”.

Intervention

1 paper studies it3 findingsUpdated

See all 1

“NAFL reversed age-associated methylation trajectories at 83.9% of CpGs showing strong differential signal in both the aging reference and NAFL-treatment.”
Non-ablative fractional laser 1940-nm treatment modulates epigenetic signatures associated with skin aging in a split-face investigationScientific reports2026doi:10.1038/s41598-026-56604-4

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • 3 of 3 findings with company ties
  • Human trial1

Studies in people

1 study gave non-ablative fractional laser 1940-nm treatment to people and measured what changed.

What did studies of Non-ablative fractional laser 1940-nm treatment find?

2

Studies of Non-ablative fractional laser 1940-nm treatment measured 2 outcomes; the most studied are age-associated methylation trajectories (1 study) and clinical improvements (1).

Age-associated methylation trajectories

downin humans1−84% cpgs

1 study

  1. Non-ablative fractional laser 1940-nm treatment decreases age-associated methylation trajectories in humans (comparison with age-associated single-CpG methylation changes) (Pearson’s R=-0.35, Spearman rho = − 0.26).

    “The resulting two-dimensional density map revealed a striking directional pattern, DNA methylation changes following NAFL treatment were anti-correlated with aging in human skin epidermis (Pearson’s R=-0.35, Spearman rho = − 0.26).”

    Human trialcomparison with age-associated single-CpG methylation changesskin epidermis6 monthsn = 22

    Laser treatment shifted aging-linked DNA marks in human skin

    Scientific reports

  2. Non-ablative fractional laser 1940-nm treatment decreases age-associated methylation trajectories in humans (CpGs showing strong differential signal in both aging reference and NAFL-treatment) (83.9% of CpGs).

    “NAFL reversed age-associated methylation trajectories at 83.9% of CpGs showing strong differential signal in both the aging reference and NAFL-treatment.”

    Human trialCpGs showing strong differential signal in both aging reference and NAFL-treatmentepidermisn = 22

    Laser treatment shifted aging-linked DNA marks in human skin

    Scientific reports

More on Age-associated methylation trajectories

Clinical improvements

upin humans1

1 study

  1. Non-ablative fractional laser 1940-nm treatment improves clinical improvements in humans (at 1-month follow-up vs contralateral untreated side).

    “Critically, brown spot reductions on the treated side were significantly greater than those on the contralateral untreated side at both 1 month (p < 0.01) and 3 months (p < 0.05), providing within-subject controlled evidence of a treatment-specific effect.”

    Human trialat 1-month follow-up vs contralateral untreated sidefacial skin6 monthsn = 20

    Laser treatment shifted aging-linked DNA marks in human skin

    Scientific reports

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 1Jul 2026: 0Aug 2026: 0Sep 2026: 0Oct 2026: 01 paper in 12 months
Scientific Reports

Laser treatment shifted aging-linked DNA marks in human skin

Changes in DNA marks opposed age-related patterns at 83.9% of sites with strong signals in both treatment and aging-reference datasets.Changes in DNA marks opposed age-related patterns at 83.9% of sites with strong signals in both treatment and aging-reference datasets.

Non-randomized trial · 22 peopleSkin
Paper

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