Age-associated methylation trajectories

1. Non-ablative fractional laser 1940-nm treatment decreases age-associated methylation trajectories in humans (comparison with age-associated single-CpG methylation changes) (Pearson’s R=-0.35, Spearman rho = − 0.26).

   “The resulting two-dimensional density map revealed a striking directional pattern, DNA methylation changes following NAFL treatment were anti-correlated with aging in human skin epidermis (Pearson’s R=-0.35, Spearman rho = − 0.26).”

   Human trialcomparison with age-associated single-CpG methylation changesskin epidermis6 monthsn = 22

   Laser treatment shifted aging-linked DNA marks in human skin

   Scientific reports·Jun 30, 2026

2. Non-ablative fractional laser 1940-nm treatment decreases age-associated methylation trajectories in humans (CpGs showing strong differential signal in both aging reference and NAFL-treatment) (83.9% of CpGs).

   “NAFL reversed age-associated methylation trajectories at 83.9% of CpGs showing strong differential signal in both the aging reference and NAFL-treatment.”

   Human trialCpGs showing strong differential signal in both aging reference and NAFL-treatmentepidermisn = 22

   Laser treatment shifted aging-linked DNA marks in human skin

   Scientific reports·Jun 30, 2026

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