Negative expectancies

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: National Institute on Aging and 1 more

Humans1

Outcomes

Depressive symptoms

upin humans1

1 study

Negative expectancies increase depressive symptoms in humans (ß = .13, p < .001).
“and depressive symptoms (ß =.13, p <.001) across a 10-year period.”
Humans10 years
Negative, but not positive, expectancies predict 10-year changes in pain outcomes for older adults with pain
The journal of pain9 Jan 2026

Latest

1 in 12 months

The Journal of Pain12 Jan

Negative, but not positive, expectancies predict 10-year changes in pain outcomes for older adults with pain

Cohort study of 5,829 peoplePopulations

Paper

Negative expectancies

Outcomes

Latest

Negative, but not positive, expectancies predict 10-year changes in pain outcomes for older adults with pain

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