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NCB-0846

Intervention

1 paper studies it2 findings

PubChem

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Animals1

Outcomes

2

NfL

downin mice1

1 study

  1. NCB-0846 decreases NfL in mice.

    “chronic dosing of NCB-0846 in the SOD1G93A mouse model of ALS significantly reduced serum neurofilament-L levels”

    AnimalsSOD1G93A mouse model of ALSchronic

    A deep-learning-based screening platform in aging-relevant human motor neurons to identify therapeutic compounds for amyotrophic lateral sclerosis

    bioRxiv (Cold Spring Harbor Laboratory)Nov 22, 2023Preprint

More on NfL

ALS-like cellular phenotypes

downin human cells1

1 study

  1. NCB-0846 decreases ALS-like cellular phenotypes in human cells.

    “identified NCB-0846, a TNIK/MAP4K7 inhibitor, as a novel compound with the ability to revert ALS-like phenotypes”

    CellsALS-associated cellular phenotypes in directly reprogrammed human neurons

    A deep-learning-based screening platform in aging-relevant human motor neurons to identify therapeutic compounds for amyotrophic lateral sclerosis

    bioRxiv (Cold Spring Harbor Laboratory)Nov 22, 2023Preprint

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