Muscle-derived stem/progenitor cells

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Frankel Family Foundation and 2 more

Animals1

Outcomes

Regenerative capacity

upin mice1

1 study

Muscle-derived stem/progenitor cells improve regenerative capacity in mice.
“Paracrine signaling from young MDSPCs enhanced the endogenous regenerative capacity of aged tissues, with effects sustained for up to 2 months post-transplantation.”
Animalsup to 2 months post-transplantation
Secretome Profiling of Young Multipotent Stem Cells Reveals Angiogenic and Immunomodulatory Mechanisms Supporting Aged Neuromuscular Health
Aging cell1 Feb 2026

Anxiety-like behavior

downin mice1

1 study

Muscle-derived stem/progenitor cells decrease anxiety-like behavior in mice.
“Systemic transplantation of young MDSPCs into naturally aged mice enhanced motor function and reduced anxiety-like behavior.”
Animalsup to 2 months post-transplantation
Secretome Profiling of Young Multipotent Stem Cells Reveals Angiogenic and Immunomodulatory Mechanisms Supporting Aged Neuromuscular Health
Aging cell1 Feb 2026

Motor function

upin mice1

1 study

Muscle-derived stem/progenitor cells improve motor function in mice.
“Systemic transplantation of young MDSPCs into naturally aged mice enhanced motor function”
Animalsup to 2 months post-transplantation
Secretome Profiling of Young Multipotent Stem Cells Reveals Angiogenic and Immunomodulatory Mechanisms Supporting Aged Neuromuscular Health
Aging cell1 Feb 2026

Latest

1 in 12 months

Aging Cell12 Feb

Secretome Profiling of Young Multipotent Stem Cells Reveals Angiogenic and Immunomodulatory Mechanisms Supporting Aged Neuromuscular Health

Experiments in miceInterventions

Paper

Muscle-derived stem/progenitor cells

Outcomes

Latest

Secretome Profiling of Young Multipotent Stem Cells Reveals Angiogenic and Immunomodulatory Mechanisms Supporting Aged Neuromuscular Health

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