Multidomain lifestyle interventions

Intervention1 paper2 findings

Outcomes

2

Executive function

upin humans1High certainty

1 study

Multidomain lifestyle interventions improve executive function in humans.
“Stratified analysis show that the intervention effect on global cognition and executive function is significant among APOE4 carriers at both 12 and 24 months.”
ReviewAPOE4 carriers with elevated dementia risk12 and 24 months
APOE4 allele modifies the effect of lifestyle interventions on cognition · Communications medicine · 6 Oct 2026

Global cognition

upin humans1High certainty

1 study

Multidomain lifestyle interventions improve global cognition in humans.
“Stratified analysis show that the intervention effect on global cognition and executive function is significant among APOE4 carriers at both 12 and 24 months.”
ReviewAPOE4 carriers with elevated dementia risk12 and 24 months
APOE4 allele modifies the effect of lifestyle interventions on cognition · Communications medicine · 6 Oct 2026

Latest

1

Communications MedicineReview10 h

APOE4 allele modifies the effect of lifestyle interventions on cognition