Multicancer early-detection test
Intervention1 paper2 findings
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.
2 of 2 findings with company ties
- Human trial1
Outcomes
1Stage III or IV cancer
no changein humans1
1 study
Stage III or IV cancer
no changein humans1
Multicancer early-detection test has no effect on stage III or IV cancer in humans (IRR 1.03, 95% CI 0.92 to 1.14, P = 0.63).
Human trial12 prespecified types of cancerthree screening rounds and at least 12 months of follow-up
Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer Diagnosis · The New England journal of medicine · 22 Sep 2026
Associations
1Stage IV cancer
downin humans1
1 study
Stage IV cancer
downin humans1
Multicancer early-detection test is associated with stage IV cancer in humans (IRR 0.86, 95% CI 0.74 to 1.00).
Human trial12 prespecified types of cancerafter 3 screening rounds
Effect of Screening with Multicancer Early-Detection Test on Late-Stage Cancer Diagnosis · The New England journal of medicine · 22 Sep 2026