Minimally evolved adenine base editors
Minimally evolved adenine base editors has been studied in 1 paper since 2026: none in people yet, 1 in cells; 1 in the past year. No study of it in people or animals has been published yet. The newest paper, Mar 18, 2026: “Precise, minimally evolved adenine base editors generated through mutation reversion analysis”.
1 paper studies it2 findingsUpdated
See all 1 papers on minimally evolved adenine base editors
At a glance
The findings reach cells, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: National Institute of General Medical Sciences and 2 more
- 2 of 2 findings with company ties
- Cells1
What did studies of minimally evolved adenine base editors find?
2Studies of minimally evolved adenine base editors measured 2 outcomes: Off-target editing and On-target editing.
Off-target editing
downin cells1
1 study
Off-target editing
downin cells1
Minimally evolved adenine base editors decrease off-target editing in cells.
“and exhibit low levels of guide-RNA-dependent and guide-RNA-independent off-target activity”
Cells
Precise, minimally evolved adenine base editors generated through mutation reversion analysis
Nature biotechnology
On-target editing
upin cells1
1 study
On-target editing
upin cells1
Minimally evolved adenine base editors increase on-target editing in cells (matching activities of ABE8e and ABE8.20 in most sequence contexts).
“ME-ABEs show narrow editing windows (similar to that of ABE7.10) and enhanced on-target editing”
Cellsmatching activities of ABE8e and ABE8.20 in most sequence contexts
Precise, minimally evolved adenine base editors generated through mutation reversion analysis
Nature biotechnology