Methadone
Intervention1 paper1 findingPubChem 4095ChEBI 167309
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper that declares the maker’s interest.
Outcomes
1Hot flushes
no changein humans1
1 study
Hot flushes
no changein humans1
Methadone has no effect on hot flushes in humans.
Human trialperimenopausal female misattributing hot flushes to opioid withdrawalfemales
The Overlapping Symptoms of Perimenopause and Opioid Withdrawal: When Hormone Therapy is "Even more Important for My Recovery than My Methadone" · Journal of addiction medicine · 11 Sep 2026