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Megakaryocyte conditioned media

Intervention

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Against: findings that point the other way from most findings on the same outcome.

  • 1 lab in 1 country
  • 1 finding against
  • Funders: National Heart, Lung, and Blood Institute and 5 more
  • Cells1

Outcomes

3

Angiogenesis

downin mouse cells1upin mouse cells1−62% to +160%

1 study

  1. Megakaryocyte conditioned media decreases angiogenesis in mouse cells (-62%).

    “62% fewer vessels formed compared to young male MK CM treatment.”

    Cellscompared to young male MK CM treatmentaged male megakaryocyte conditioned mediabone marrowmales

    The effects of young and aged, male and female megakaryocyte conditioned media on angiogenic properties of endothelial cells

    AgingNov 22, 2024

  2. Megakaryocyte conditioned media increases angiogenesis in mouse cells (160%).

    “Likewise, young male MK CM increased vessel formation by 160%.”

    Cellsyoung male megakaryocyte conditioned mediabone marrowmales

    The effects of young and aged, male and female megakaryocyte conditioned media on angiogenic properties of endothelial cells

    AgingNov 22, 2024

  3. Megakaryocyte conditioned media improves angiogenesis in mouse cells (>115%).

    “Female MK CM, regardless of age, caused a >65% increase in BMEC proliferation and improved vessel formation by >115%.”

    Cellsfemale megakaryocyte conditioned mediabone marrow

    The effects of young and aged, male and female megakaryocyte conditioned media on angiogenic properties of endothelial cells

    AgingNov 22, 2024

More on Angiogenesis

Endothelial cell migration

upin mouse cells1

1 study

  1. Megakaryocyte conditioned media improves endothelial cell migration in mouse cells (>2500%).

    “Aged female MK CM improved migration by over 2500%.”

    Cellsaged female megakaryocyte conditioned mediabone marrowfemales

    The effects of young and aged, male and female megakaryocyte conditioned media on angiogenic properties of endothelial cells

    AgingNov 22, 2024

Endothelial cell proliferation

upin mouse cells1

1 study

  1. Megakaryocyte conditioned media increases endothelial cell proliferation in mouse cells (>65%).

    “Female MK CM, regardless of age, caused a >65% increase in BMEC proliferation and improved vessel formation by >115%.”

    Cellsfemale megakaryocyte conditioned mediabone marrow

    The effects of young and aged, male and female megakaryocyte conditioned media on angiogenic properties of endothelial cells

    AgingNov 22, 2024

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