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Maternal age

Exposure

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Darwin Trust of Edinburgh and 4 more
  • Animals1

Outcomes

1

Lifetime reproductive success

upin O. aries1

1 study

  1. Maternal age increases lifetime reproductive success in O. aries.

    “Increased adult reproductive success in sons of middle-aged mothers, compared to young and old mothers”

    Animalscompared to young and old mothersmales

    Persistent maternal age effects on male offspring fitness traits in a wild mammal population

    Evolution letters22 Jul 2025

Associations

1

Lifespan

mixedin O. aries1

1 study

  1. Maternal age is associated with lifespan in O. aries.

    “adult lifespan and lifetime reproductive success were only influenced by maternal age in sons and not in daughters”

    Animalsamong offspring that survived their first yearmales

    Persistent maternal age effects on male offspring fitness traits in a wild mammal population

    Evolution letters22 Jul 2025

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