JWH-133

JWH-133 has been studied in 2 papers since 2016: none in people yet, 1 in animals, 1 review. The research so far is in animals. The newest paper, Jul 29, 2021: “Pharmacological potential of JWH133, a cannabinoid type 2 receptor agonist in neurodegenerative, neurodevelopmental and neuropsychiatric diseases”.

Intervention

2 papers study it4 findingsUpdated

PubChemChEBI

See all 2 papers on JWH-133

At a glance

The findings reach mice, none yet in people. 1 lab in 1 country.

Mice: a single group. Cells, worms or flies and humans: nothing yet.
  • 1 lab in 1 country
  • Funders: Brain & Behavior Research Foundation and 7 more
  • Animals1

What did studies of JWH-133 find?

4

Studies of JWH-133 measured 4 outcomes, among them neurogenesis, inflammation and neuronal oxidative damage.

neurogenesis

upin reviews1

1 study
  1. JWH-133 increases neurogenesis.

    “JWH133 showed to protect neurons from oxidative damage and inflammation, promote neuronal survival and neurogenesis”

    Reviewneuron

    Pharmacological potential of JWH133, a cannabinoid type 2 receptor agonist in neurodegenerative, neurodevelopmental and neuropsychiatric diseases

    European journal of pharmacology

Inflammation

downin reviews1

1 study
  1. JWH-133 decreases inflammation.

    “JWH133 showed to protect neurons from oxidative damage and inflammation”

    Reviewneuron

    Pharmacological potential of JWH133, a cannabinoid type 2 receptor agonist in neurodegenerative, neurodevelopmental and neuropsychiatric diseases

    European journal of pharmacology

More on Inflammation

Neuronal oxidative damage

downin reviews1

1 study
  1. JWH-133 protects against neuronal oxidative damage.

    “JWH133 showed to protect neurons from oxidative damage and inflammation”

    Reviewneuron

    Pharmacological potential of JWH133, a cannabinoid type 2 receptor agonist in neurodegenerative, neurodevelopmental and neuropsychiatric diseases

    European journal of pharmacology

Glucose uptake

upin mice1

1 study
  1. JWH-133 increases glucose uptake in mice.

    “both selective (JWH133 and GP1a) as well as non-selective (WIN55212-2) CB2R agonists, but not the CB1R-selective agonist, ACEA, stimulate glucose uptake”

    Animals

    Stimulation of brain glucose uptake by cannabinoid CB2 receptors and its therapeutic potential in Alzheimer's disease

    Neuropharmacology

More on Glucose uptake

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