Job strain

3 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: Centers for Disease Control and Prevention and 6 more

Humans2

Associations

Cardiovascular disease mortality

upin humans1HR 1.14

1 study

Job strain is associated with cardiovascular disease mortality in humans (HR 1.14, 95% CI 1.01-1.27).
Humansadjusted for sex, age, education, and occupational classmedian follow-up >23 years
Job strain and cardiovascular mortality over long-term follow-up: a harmonized multicohort individual participant data meta-analysis
Scandinavian journal of work, environment & health7 Sep 2026

Severe menopausal symptoms

upin humans1RR 1.3

1 study