Ishe
Intervention1 paper4 findings
A preprint reports that, in an uncontrolled human feasibility trial, daily Ishe sessions over 30 days are associated with lower loneliness and depressive symptoms in older adults living alone, with complete adherence and unchanged cognitive screening performance.
- Human trial1
Outcomes
1Cognitive screening performance
no changein humans1Very low certainty
1 study
Cognitive screening performance
no changein humans1Very low certainty
Ishe has no effect on cognitive screening performance in humans (SMMSE 29.3 ± 1.1 to 29.6 ± 0.7; SPMSQ 0–2 errors).
Human trialcommunity-dwelling older adults living alone; uncontrolled baseline-to-endline comparisonone daily voice session30 daysn = 10
Turkish-language Large Language Model-supported Voice Companion for Cognitive Monitoring via Social Artificial Intelligence in Older People Living Alone: A Single-Arm Pilot Feasibility Study · Research Square · 6 Oct 2026 · Preprint
Associations
3Depressive symptoms
downin humans1Very low certainty
1 study
Depressive symptoms
downin humans1Very low certainty
Ishe is associated with depressive symptoms in humans (GDS-15 4.50 ± 4.22 to 2.30 ± 2.26; Cohen’s dz = 0.66).
Human trialcommunity-dwelling older adults living alone; uncontrolled baseline-to-endline comparisonone daily voice session30 daysn = 10
Turkish-language Large Language Model-supported Voice Companion for Cognitive Monitoring via Social Artificial Intelligence in Older People Living Alone: A Single-Arm Pilot Feasibility Study · Research Square · 6 Oct 2026 · Preprint
Loneliness
downin humans1Very low certainty
1 study
Loneliness
downin humans1Very low certainty
Ishe is associated with loneliness in humans (DJGLS 8.50 ± 5.28 to 5.70 ± 4.92; Cohen’s dz = 0.98).
Human trialcommunity-dwelling older adults living alone; uncontrolled baseline-to-endline comparisonone daily voice session30 daysn = 10
Turkish-language Large Language Model-supported Voice Companion for Cognitive Monitoring via Social Artificial Intelligence in Older People Living Alone: A Single-Arm Pilot Feasibility Study · Research Square · 6 Oct 2026 · Preprint
Daily voice session adherence
upin humans1Very low certainty
1 study
Daily voice session adherence
upin humans1Very low certainty
Ishe is associated with daily voice session adherence in humans (All 30 sessions completed; retention 100%).
Human trialcommunity-dwelling older adults living alone; single-arm feasibility studyTurkish-language LLM-supported mobile voice companionone daily voice session30 daysn = 10
Turkish-language Large Language Model-supported Voice Companion for Cognitive Monitoring via Social Artificial Intelligence in Older People Living Alone: A Single-Arm Pilot Feasibility Study · Research Square · 6 Oct 2026 · Preprint