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Iron dextran

Intervention

4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • 10 trials, 2 with no results posted
  • Funder: National Research Foundation of Korea

Outcomes

4

Exploratory activity

downin mice1

1 study

  1. Iron dextran decreases exploratory activity in mice.

    “excessive iron was associated with reduced exploratory activity and showed trends toward impaired spatial working memory in older mice.”

    Animals

    Excess iron may accelerate amyloid beta accumulation in the brains of older mice

    Neurobiology of aging13 Dec 2025

Ferritin

upin mice1

1 study

  1. Iron dextran increases ferritin in mice.

    “ferritin expression increased with IO and showed as plaques in older mice regardless of IO.”

    Animalsin older micebrain

    Excess iron may accelerate amyloid beta accumulation in the brains of older mice

    Neurobiology of aging13 Dec 2025

More on Ferritin

Abeta 42/40 ratio

upin mice1

1 study

  1. Iron dextran increases Abeta 42/40 ratio in mice.

    “The hippocampal Aβ 42/40 ratio was also increased in this group.”

    Animalsin older miceintraperitonealhippocampus0.5 g/kg5 days/week for 4 weeks

    Excess iron may accelerate amyloid beta accumulation in the brains of older mice

    Neurobiology of aging13 Dec 2025

More on Abeta 42/40 ratio

Amyloid beta aggregation

upin mice1

1 study

  1. Iron dextran increases amyloid beta aggregation in mice.

    “Amyloid beta (Aβ) aggregation was observed in the entorhinal cortex and hippocampus, with higher burden in the older IO group.”

    Animalsin older miceintraperitonealbrain0.5 g/kg5 days/week for 4 weeks

    Excess iron may accelerate amyloid beta accumulation in the brains of older mice

    Neurobiology of aging13 Dec 2025

More on Amyloid beta aggregation

Trial sponsors

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