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Interleukin 4 over-expressing mesenchymal stem cells

Intervention

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases and 2 more
  • Animals1

Outcomes

2

M2/M1 ratio

upin mice1

1 study

  1. Interleukin 4 over-expressing mesenchymal stem cells increase M2/M1 ratio in mice.

    “significant increase in the M2/M1 ratio.”

    Animalsfemoral diaphyseal critical-size bone defectfemur6 weeks

    Ageing attenuates bone healing by mesenchymal stem cells in a microribbon hydrogel with a murine long bone critical-size defect model

    Immunity & ageing : I & AMar 12, 2022

More on M2/M1 ratio

Bone formation

upin mice1

1 study

  1. Interleukin 4 over-expressing mesenchymal stem cells increase bone formation in mice.

    “bone formation was markedly enhanced in the IL4-MSC group.”

    Animalsfemoral diaphyseal critical-size bone defectfemur6 weeks

    Ageing attenuates bone healing by mesenchymal stem cells in a microribbon hydrogel with a murine long bone critical-size defect model

    Immunity & ageing : I & AMar 12, 2022

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