Influenza infection

1. Influenza infection decreases expression of positive regulators of muscle mass and myogenesis components in mice.

   “Infection also decreased expression of positive regulators of muscle mass and myogenesis components to a greater degree in aged mice.”

   Animalsgreater decrease in aged miceskeletal muscle

   Aging augments the impact of influenza respiratory tract infection on mobility impairments, muscle-localized inflammation, and muscle atrophy

   Aging·Feb 10, 2016

More on Expression of positive regulators of muscle mass and myogenesis components

1. Influenza infection increases muscle atrophy and proteolysis gene expression in mice.

   “Skeletal muscle expression of genes involved in inflammation, as well as muscle atrophy and proteolysis, increased during influenza infection”

   Animalselevated and prolonged peak in aged miceskeletal muscle

   Aging augments the impact of influenza respiratory tract infection on mobility impairments, muscle-localized inflammation, and muscle atrophy

   Aging·Feb 10, 2016

More on Muscle atrophy and proteolysis gene expression

1. Influenza infection increases inflammatory gene expression in mice.

   “Skeletal muscle expression of genes involved in inflammation, as well as muscle atrophy and proteolysis, increased during influenza infection”

   Animalselevated and prolonged peak in aged miceskeletal muscle

   Aging augments the impact of influenza respiratory tract infection on mobility impairments, muscle-localized inflammation, and muscle atrophy

   Aging·Feb 10, 2016

More on Inflammatory gene expression

1. Influenza infection impairs mobility in mice.

   “Infected young and aged mice demonstrated decreased mobility and altered gait kinetics.”

   Animalsinfluenza infection; declines more prominent in aged mice

   Aging augments the impact of influenza respiratory tract infection on mobility impairments, muscle-localized inflammation, and muscle atrophy

   Aging·Feb 10, 2016