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Hydrogel-encapsulated CCL2-IL1RA ipscs

Intervention

1 paper studies it1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Center of Regenerative Medicine, Washington University in St. Louis and 8 more
  • Animals1

Outcomes

1

Inflammatory arthritis

downin mice1

1 study

  1. Hydrogel-encapsulated CCL2-IL1RA ipscs decrease inflammatory arthritis in mice (nearly complete abolishment).

    “showed significant therapeutic efficacy in the K/BxN model of inflammatory arthritis, with nearly complete abolishment of disease severity in the front paws.”

    Animalsin K/BxN model of inflammatory arthritisfront paws

    Hydrogel Encapsulation of Genome-Engineered Stem Cells for Long-Term Self-Regulating Anti-Cytokine Therapy

    Gels (Basel, Switzerland)

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