Homoharringtonine

1 paper5 findings

PubChem 285033 ChEBI 71019 MeSH D000077863

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Canadian Institutes of Health Research and 6 more

Animals1

Outcomes

Lifespan

upin mice1

1 study

Homoharringtonine extends lifespan in mice.
“Importantly, we found that HHT treatment delays aging and extends the lifespan in progeroid and aged mice.”
Animalsprogeroid and aged mice
Homoharringtonine exhibits senotherapeutic activity that mitigates diet- and age-associated obesity and insulin resistance and extends lifespan in mice
Nature communications31 Mar 2026

Age-associated adipose tissue phenotypes

downin human cells1

1 study

Homoharringtonine decreases age-associated adipose tissue phenotypes in human cells.
“Moreover, HHT treatment attenuates age-associated phenotypes of human adipose tissue.”
Cellsadipose tissue
Homoharringtonine exhibits senotherapeutic activity that mitigates diet- and age-associated obesity and insulin resistance and extends lifespan in mice
Nature communications31 Mar 2026

White adipose tissue inflammation

downin mice1

1 study

Homoharringtonine decreases white adipose tissue inflammation in mice.
“targeting senescent adipocytes and preadipocytes to improve WAT function and reduce WAT inflammation.”
Animalsdiet- or age-induced metabolic abnormalitieswhite adipose tissuemales
Homoharringtonine exhibits senotherapeutic activity that mitigates diet- and age-associated obesity and insulin resistance and extends lifespan in mice
Nature communications31 Mar 2026

Metabolic abnormalities

downin mice1

1 study

Homoharringtonine prevents metabolic abnormalities in mice.
“HHT treatment prevents diet- or age-induced metabolic abnormalities in male mice”
Animalsdiet- or age-induced metabolic abnormalitiesmales
Homoharringtonine exhibits senotherapeutic activity that mitigates diet- and age-associated obesity and insulin resistance and extends lifespan in mice
Nature communications31 Mar 2026

Cellular senescence

downin human cells1

1 study

Homoharringtonine decreases cellular senescence in human cells.
“manifests senotherapeutic activity in vitro in multiple cell types including human preadipocytes, while inflicting minimal cytotoxicity to non-senescent cells.”
Cellspreadipocyte
Homoharringtonine exhibits senotherapeutic activity that mitigates diet- and age-associated obesity and insulin resistance and extends lifespan in mice
Nature communications31 Mar 2026

Latest

1 in 12 months

Nature Communications31 Mar