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Home-based exercise

Intervention

3 papers5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funders: Coordenação de Aperfeiçoamento de Pessoal de Nível Superior and 3 more
  • Human trial1

Outcomes

5

Dynamic balance

upin humans1

1 study

  1. Home-based exercise improves dynamic balance in humans (SMD 0.81, 95% CI 0.49 to 1.13).

    “and a large effect on dynamic balance [SMD]: 0.81; 95% CI: 0.49 to 1.13).”

    Reviewduring the COVID-19 pandemic

    Effects of home-based exercise on the mental and physical health of older adults: a systematic review and meta-analysis of randomized clinical trials

    Aging & mental health30 Sep 2025

Depressive symptoms

downin humans1

1 study

  1. Home-based exercise decreases depressive symptoms in humans (SMD -0.38, 95% CI -0.65 to -0.12).

    “Home-based exercise presented a small effect on depressive symptoms (standard mean difference [SMD]: -0.38; 95% Confidence Interval [CI]: -0.65 to -0.12)”

    Reviewduring the COVID-19 pandemic

    Effects of home-based exercise on the mental and physical health of older adults: a systematic review and meta-analysis of randomized clinical trials

    Aging & mental health30 Sep 2025

More on Depressive symptoms

Digit Symbol Substitution Test

upin humans1

1 study

  1. Home-based exercise improves Digit Symbol Substitution Test in humans (estimated mean difference 2.51).

    “Digit Symbol Substitution Test at 12 months (estimated mean difference= 2.51; 95% CI:[0.81, 4.21]; p=0.00)”

    Human trialin participants with slow gait speed12 monthsn = 134

    GAIT SPEED MODERATES EFFICACY OF HOME-BASED EXERCISE ON FALLS IN OLDER ADULTS WITH PREVIOUS FALL

    GSA 2024 abstract31 Dec 2024

More on Digit Symbol Substitution Test

Timed Up-and-Go

upin humans1

1 study

  1. Home-based exercise improves Timed Up-and-Go in humans (estimated mean difference -4.05).

    “EX participants with slow gait improved: 1) Timed Up-and-Go at 6 months (estimated mean difference= -4.05; 95% CI:[-6.82, -1.27]; p= 0.00)”

    Human trialin participants with slow gait speed6 monthsn = 134

    GAIT SPEED MODERATES EFFICACY OF HOME-BASED EXERCISE ON FALLS IN OLDER ADULTS WITH PREVIOUS FALL

    GSA 2024 abstract31 Dec 2024

More on Timed Up-and-Go

Falls

downin humans1

1 study

  1. Home-based exercise decreases falls in humans (IRR 0.56, -44%).

    “For participants with slow gait speed, EX reduced fall rates by 44% at 6 months (IRR=0.56; 95% CI:[0.33, 0.95]; p= 0.03) compared with SC”

    Human trialin participants with slow gait speed6 monthsn = 134

    GAIT SPEED MODERATES EFFICACY OF HOME-BASED EXERCISE ON FALLS IN OLDER ADULTS WITH PREVIOUS FALL

    GSA 2024 abstract31 Dec 2024

Funding

3 grants since 2017

National Institute for Health and Care Research£3.9mFundacao de Amparo a Pesquisa do Estado de Sao Paulo

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