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Heligmosomoides polygyrus infection

Intervention

2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funder: Japan Science and Technology Agency

What did studies of Heligmosomoides polygyrus infection find?

1

Studies of Heligmosomoides polygyrus infection measured 1 outcome; the most studied are Bacillota/Bacteroidota ratio (1 study).

Bacillota/Bacteroidota ratio

downin mice1

1 study

  1. Heligmosomoides polygyrus infection decreases Bacillota/Bacteroidota ratio in mice.

    “Hp infection induced a pronounced shift in the cecal microbiota composition of young mice, notably a reduced Bacillota/Bacteroidota ratio (F/B) ratio”

    AnimalsChange much less evident in aged micececum

    Aging impairs type 2 immune responses to nematodes associated with reduced gut microbiota responsiveness

    Scientific reports

More on Bacillota/Bacteroidota ratio

What is Heligmosomoides polygyrus infection linked with?

1

Studies link Heligmosomoides polygyrus infection with 1 measure, most often short-chain fatty acids (1 study).

Short-chain fatty acids

mixedin mice1

1 study

  1. Heligmosomoides polygyrus infection is associated with short-chain fatty acids in mice.

    “Correspondingly, cecal SCFA levels-particularly acetate and propionate-increased in Hp infected young mice but decreased in aged counterparts.”

    AnimalsIncreased in young mice but decreased in aged mice following infectioncecum

    Aging impairs type 2 immune responses to nematodes associated with reduced gut microbiota responsiveness

    Scientific reports

More on Short-chain fatty acids