Hbsag-aβ(1-11) DNA vaccine

1. Hbsag-aβ(1-11) DNA vaccine increases anti-Aβ antibody in mice.

   “elicit high levels of anti-Aβ antibody both in young and old mice”

   Animals

   DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid β-peptide attenuates disease progression and prolongs survival in a mouse model of Alzheimer's disease

   Vaccine·Jan 14, 2012

More on anti-Aβ antibody

1. Hbsag-aβ(1-11) DNA vaccine extends lifespan in mice.

   “significantly increased life span”

   Animalsin AD model 3xTgAD mice

   DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid β-peptide attenuates disease progression and prolongs survival in a mouse model of Alzheimer's disease

   Vaccine·Jan 14, 2012

1. Hbsag-aβ(1-11) DNA vaccine improves cognitive function in mice.

   “ameliorated cognitive impairments”

   Animalsin AD model 3xTgAD mice

   DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid β-peptide attenuates disease progression and prolongs survival in a mouse model of Alzheimer's disease

   Vaccine·Jan 14, 2012

1. Hbsag-aβ(1-11) DNA vaccine decreases Aβ plaques in mice.

   “the vaccine reduced Aβ plaques”

   Animalsin AD model 3xTgAD mice

   DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid β-peptide attenuates disease progression and prolongs survival in a mouse model of Alzheimer's disease

   Vaccine·Jan 14, 2012

More on Aβ plaques