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Group i mglur agonist

Intervention

1 paper1 finding

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional and 1 more
  • Cells1

Outcomes

1

Afterdepolarization plateau

upin rats1

1 study

  1. Group i mglur agonist induces afterdepolarization plateau in rats.

    “stimulation of group I mGluRs causes a switch from afterhyperpolarization to an afterdepolarization plateau that eases a persistent but non-rhythmic firing discharge.”

    Animalsupon pharmacological stimulation of group I mGluRshippocampal area CA3

    Aging-related adaptations of metabotropic glutamate receptors within the CA3 region of the rat hippocampus

    Neurobiology of aging3 Sep 2025

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