Grabody b-fused bispecific antibodies

Intervention

1 paper2 findings

  • 1 lab in 1 country
  • 2 of 2 findings with company ties
  • Animals1

Outcomes

2

Clathrin-mediated endocytosis

upin human cells1

1 study
  1. Grabody b-fused bispecific antibodies induce clathrin-mediated endocytosis in human cells (within 30 seconds).

    “GB BsAbs rapidly internalized within 30 seconds, localized closely with filamentous actin (F‐actin), and even induced the reorganization of F‐actin with various morphologies.”

    Cellsin human BECs

    Grabody B, an IGF1R‐targeting Molecular Shuttle, Sustains Brain Penetration of Therapeutic Antibody in Aged Mice by Multiple, Novel Transcytosis Pathways

    AAIC 2025 abstract24 Dec 2025

More on Clathrin-mediated endocytosis

Brain exposure

upin mice1

1 study
  1. Grabody b-fused bispecific antibodies increase brain exposure in mice.

    “Grabody B‐fused bispecific antibodies (GB BsAbs) were proven to have increased brain exposure and efficacy compared to monoclonal antibodies (mAbs).”

    Animalscompared to mAbsbrain

    Grabody B, an IGF1R‐targeting Molecular Shuttle, Sustains Brain Penetration of Therapeutic Antibody in Aged Mice by Multiple, Novel Transcytosis Pathways

    AAIC 2025 abstract24 Dec 2025

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