Glucagon receptor/GLP-1 receptor dual agonists

Intervention

1 paper3 findings

Outcomes

3

Hepatic fibrosis

downin humans1

1 study
  1. Glucagon receptor/GLP-1 receptor dual agonists decrease hepatic fibrosis in humans.

    “In early clinical trials, some dual agonists substantially reduced body weight, hepatic steatosis, and hepatic fibrosis.”

    ReviewEarly clinical trials of some dual agonistsliver

    The Power of Two: Harnessing Dual Glucagon and Incretin Signaling for Treatment of Obesity and Metabolic Dysfunction-Associated Steatohepatitis-A Narrative Review with a Translational Focus

    Obesity reviews : an official journal of the International Association for the Study of Obesity11 Oct 2026

More on Hepatic fibrosis

Hepatic steatosis

downin humans1

1 study
  1. Glucagon receptor/GLP-1 receptor dual agonists decrease hepatic steatosis in humans.

    “In early clinical trials, some dual agonists substantially reduced body weight, hepatic steatosis, and hepatic fibrosis.”

    ReviewEarly clinical trials of some dual agonistsliver

    The Power of Two: Harnessing Dual Glucagon and Incretin Signaling for Treatment of Obesity and Metabolic Dysfunction-Associated Steatohepatitis-A Narrative Review with a Translational Focus

    Obesity reviews : an official journal of the International Association for the Study of Obesity11 Oct 2026

More on Hepatic steatosis

Body weight

downin humans1

1 study
  1. Glucagon receptor/GLP-1 receptor dual agonists decrease body weight in humans.

    “In early clinical trials, some dual agonists substantially reduced body weight, hepatic steatosis, and hepatic fibrosis.”

    ReviewEarly clinical trials of some dual agonists

    The Power of Two: Harnessing Dual Glucagon and Incretin Signaling for Treatment of Obesity and Metabolic Dysfunction-Associated Steatohepatitis-A Narrative Review with a Translational Focus

    Obesity reviews : an official journal of the International Association for the Study of Obesity11 Oct 2026

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