GL-II-73
GL-II-73 has been studied in 1 paper since 2020: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Oct 18, 2020: “Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation”.
None of its findings points the other way.
- 1 lab in 1 country
- Funders: Campbell Family Mental Health Research Institute and 5 more
- Animals1
What did studies of GL-II-73 find?
3Studies of GL-II-73 measured 3 outcomes; the most studied are dendritic branching complexity and spine numbers (1 study), age-related dendritic shrinkage and spine loss (1) and working memory (1).
Dendritic branching complexity and spine numbers
upin mouse cells1
1 study
Dendritic branching complexity and spine numbers
upin mouse cells1
GL-II-73 increases dendritic branching complexity and spine numbers in mouse cells (cortical neurons in vitro).
“GL-II-73, a novel ligand with positive allosteric modulatory activity at α5-GABAA-R (α5-PAM), increases dendritic branching complexity and spine numbers of cortical neurons in vitro”
Cellscortical neurons in vitrocortical neuron
Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation
Cerebral cortex (New York, N.Y. : 1991)
Age-related dendritic shrinkage and spine loss
downin mice1
1 study
Age-related dendritic shrinkage and spine loss
downin mice1
GL-II-73 decreases age-related dendritic shrinkage and spine loss in mice (old mice).
“chronic treatment (3 months) significantly reverses age-related dendritic shrinkage and spine loss in frontal cortex and hippocampus”
Animalsold micefrontal cortex and hippocampus3 months
Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation
Cerebral cortex (New York, N.Y. : 1991)
Working memory
upin mice1
1 study
Working memory
upin mice1
GL-II-73 improves working memory in mice (old mice).
“we confirm that α5-PAM reverses age-related working memory deficits”
Animalsold mice
Reversal of Age-Related Neuronal Atrophy by α5-GABAA Receptor Positive Allosteric Modulation
Cerebral cortex (New York, N.Y. : 1991)