Gdp-l-fucose
- 1 lab in 1 country
- Funders: Bill and Melinda Gates Foundation and 2 more
- Animals1
Outcomes
2Xenobiotic efflux
upin mice1
1 study
Xenobiotic efflux
upin mice1
Gdp-l-fucose improves xenobiotic efflux in mice.
“activates c-Jun-driven ABCB1 expression, thereby restoring xenobiotic efflux.”
Animalsintestine
Nature communications27 Nov 2025
ABCB1
upin mice1
1 study
ABCB1
upin mice1
Gdp-l-fucose increases ABCB1 in mice.
“This metabolite directly promotes phosphorylation of the eukaryotic translation initiation factor 4E (eIF4E) and activates c-Jun-driven ABCB1 expression, thereby restoring xenobiotic efflux.”
Animalsintestine
Nature communications27 Nov 2025
Latest
1 in 12 monthsNature Communications
Odoribacter splanchnicus rescues aging-related intestinal P-glycoprotein damage via GDP-L-fucose secretion
Experiments in miceGut and microbiome