Gdp-l-fucose

  • 1 lab in 1 country
  • Funders: Bill and Melinda Gates Foundation and 2 more
  • Animals1

Outcomes

2

Xenobiotic efflux

upin mice1

1 study
  1. Gdp-l-fucose improves xenobiotic efflux in mice.

    “activates c-Jun-driven ABCB1 expression, thereby restoring xenobiotic efflux.”

    Animalsintestine

    Odoribacter splanchnicus rescues aging-related intestinal P-glycoprotein damage via GDP-L-fucose secretion

    Nature communications27 Nov 2025

ABCB1

upin mice1

1 study
  1. Gdp-l-fucose increases ABCB1 in mice.

    “This metabolite directly promotes phosphorylation of the eukaryotic translation initiation factor 4E (eIF4E) and activates c-Jun-driven ABCB1 expression, thereby restoring xenobiotic efflux.”

    Animalsintestine

    Odoribacter splanchnicus rescues aging-related intestinal P-glycoprotein damage via GDP-L-fucose secretion

    Nature communications27 Nov 2025

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