Neurotoxicology
Traffic pollution accelerated brain plaque buildup in rats
An experiment in 432 Alzheimer’s-prone rats assessed brains at 4–15 months, finding the most prominent effects with light-duty vehicle particles compared with filtered…An experiment in 432 Alzheimer’s-prone rats assessed brains at 4–15 months, finding the most prominent effects with light-duty vehicle particles compared with filtered air.
Rat studyMechanisms
Who was studiedMale and female TgF344-AD rats, up to 14 months, against rats breathing filtered air
What changedAmyloid deposits accumulated faster in the entorhinal cortex of pollution-exposed rats than in rats breathing filtered air
The catchThe plaque measure includes early aggregates; staining for mature plaques showed no exposure differences