Exceptional parental longevity
Intervention1 paper6 findings
- Humans1
Outcomes
3Cancer
no changein humans1Low certainty
1 study
Cancer
no changein humans1Low certainty
Exceptional parental longevity has no effect on cancer in humans.
Humansoffspring with at least 1 parent reaching age 100 years
Exceptional Parental Longevity and Onset of Morbidity and Mortality Across Cohorts · JAMA network open · 3 Aug 2026
Age at onset of hypertension
upin humans1Low certainty
1 study
Age at onset of hypertension
upin humans1Low certainty
Exceptional parental longevity improves age at onset of hypertension in humans (delay of 5.21 years (95% CI, 2.13-8.29 years)).
Humansoffspring with at least 1 parent reaching age 100 years
Exceptional Parental Longevity and Onset of Morbidity and Mortality Across Cohorts · JAMA network open · 3 Aug 2026
Age at death
upin humans1Low certainty
1 study
Age at death
upin humans1Low certainty
Exceptional parental longevity improves age at death in humans (delay of 3.12 years (95% CI, 0.96-5.28 years)).
Humansoffspring with at least 1 parent reaching age 100 years
Exceptional Parental Longevity and Onset of Morbidity and Mortality Across Cohorts · JAMA network open · 3 Aug 2026
Associations
3Hypertension
downin humans1HR 0.68Low certainty
1 study
Hypertension
downin humans1HR 0.68Low certainty
Exceptional parental longevity lowers the risk of hypertension in humans (HR 0.68, 95% CI 0.62-0.75).
Humansoffspring with at least 1 parent reaching age 100 years
Exceptional Parental Longevity and Onset of Morbidity and Mortality Across Cohorts · JAMA network open · 3 Aug 2026
Cardiovascular disease
downin humans1HR 0.67Low certainty
1 study
Cardiovascular disease
downin humans1HR 0.67Low certainty
Exceptional parental longevity lowers the risk of cardiovascular disease in humans (HR 0.67, 95% CI 0.46-0.97).
Humansoffspring with at least 1 parent reaching age 100 years
Exceptional Parental Longevity and Onset of Morbidity and Mortality Across Cohorts · JAMA network open · 3 Aug 2026
Mortality
downin humans1HR 0.58Low certainty
1 study
Mortality
downin humans1HR 0.58Low certainty
Exceptional parental longevity lowers the risk of mortality in humans (HR 0.58, 95% CI 0.41-0.81).
Humansoffspring with at least 1 parent reaching age 100 years
Exceptional Parental Longevity and Onset of Morbidity and Mortality Across Cohorts · JAMA network open · 3 Aug 2026