Ex vivo heart perfusion
Ex vivo heart perfusion has been studied in 3 papers since 2026: none in people yet, 1 in animals, 2 reviews; 3 in the past year. The research so far is in animals. The newest paper, Oct 22, 2026: “Ex Vivo Heart Perfusion Versus Cold Storage in Prolonged Preservation Period: A Juvenile Porcine Experimental Model”.
3 papers study it4 findingsUpdated
2 new papers in 30 daysSee all 3 papers on ex vivo heart perfusion
At a glance
The findings reach mice, none yet in people. 1 lab in 1 country.
None of its findings points the other way.
- 1 lab in 1 country
- Animals1
What did studies of ex vivo heart perfusion find?
4Studies of ex vivo heart perfusion measured 4 outcomes, among them neutrophil infiltration, arterial lactate and cardiac output.
Neutrophil infiltration
upin pigs1
1 study
Neutrophil infiltration
upin pigs1
Ex vivo heart perfusion increases neutrophil infiltration in pigs (compared with cold storage) (p = 0.033).
“increased neutrophil infiltration (p = 0.033) at 8 hours”
Animalscompared with cold storagenormothermicheart8 hours
ASAIO journal (American Society for Artificial Internal Organs : 1992)
Arterial lactate
upin pigs1
1 study
Arterial lactate
upin pigs1
Ex vivo heart perfusion increases arterial lactate in pigs during working-mode perfusion after preservation, compared with cold storage (p < 0.001).
“arterial lactate levels during WM (p < 0.001), and NFκB-p65 levels (p = 0.002) at 6 hours”
Animalsduring working-mode perfusion after preservation, compared with cold storagenormothermicheart6 hours
ASAIO journal (American Society for Artificial Internal Organs : 1992)
Cardiac output
downin pigs1
1 study
Cardiac output
downin pigs1
Ex vivo heart perfusion decreases cardiac output in pigs (compared with cold storage) (90 vs. 120% of normal; p = 0.026).
“lower cardiac output (90 vs. 120% of normal, p = 0.026)”
Animalscompared with cold storagenormothermicheart8 hours
ASAIO journal (American Society for Artificial Internal Organs : 1992)
Left atrial pressure
upin pigs1
1 study
Left atrial pressure
upin pigs1
Ex vivo heart perfusion increases left atrial pressure in pigs (compared with cold storage) (6 vs. 0 mm Hg; p = 0.011).
“Compared to CS, EVHP hearts showed higher left atrial pressure (6 vs. 0 mm Hg, p = 0.011)”
Animalscompared with cold storagenormothermicheart6 hours
ASAIO journal (American Society for Artificial Internal Organs : 1992)