Esomeprazole
Intervention1 paper2 findingsPubChem 9568614ChEBI 50275
C · W · M · H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
Labs are independent when their papers share no last author and no institution.
Against: findings that point the other way from most findings on the same outcome.
No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.
Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.
Funders: Chinese Pharmaceutical Association and 1 more
Outcomes
1Fractures
no changein humans1OR 1.16
1 study
Fractures
no changein humans1OR 1.16
Esomeprazole has no effect on fractures in humans (OR 1.16, 95%CI 0.97-1.38).
Humanscompared with non-PPI usersn = 257,445
Differential fracture risk among proton pump inhibitors in older adults: evidence network and pharmacovigilance validation · Frontiers in pharmacology · 19 Aug 2026
Associations
1Osteoporosis
upin humans1
1 study
Osteoporosis
upin humans1
Esomeprazole raises the risk of osteoporosis in humans (ROR 2.44, 95%CI 1.41-4.20).
Humansnarrow-scope MedDRA SMQ analysis for Osteoporosis/Osteopenia in FAERS
Differential fracture risk among proton pump inhibitors in older adults: evidence network and pharmacovigilance validation · Frontiers in pharmacology · 19 Aug 2026