Engineered IL-10 variant

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Chan Zuckerberg Initiative and 6 more

Animals1

Outcomes

Microglial function

upin reviews1

1 study

Engineered IL-10 variant improves microglial function.
“reveal the beneficial effects of an engineered IL-10 variant that functionally uncouples pro- and anti-inflammatory signaling in microglia.”
Reviewbrain aging
Shedding light on interventions for brain aging
Immunity10 Feb 2026

Cognitive function

upin mice1

1 study

Engineered IL-10 variant improves cognitive function in mice.
“An engineered IL-10 variant that uncouples pro- and anti-inflammatory responses positively impacted the transcriptome of multiple cell types, enhanced neurogenesis, and improved cognition in aged mice.”
Animalsdirect brain delivery in aged mice
Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition
Immunity30 Jan 2026

Neurogenesis

upin mice1

1 study

Engineered IL-10 variant increases neurogenesis in mice.
“An engineered IL-10 variant that uncouples pro- and anti-inflammatory responses positively impacted the transcriptome of multiple cell types, enhanced neurogenesis, and improved cognition in aged mice.”
Animalsdirect brain delivery in aged mice
Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition
Immunity30 Jan 2026

Latest

1 in 12 months

Immunity1 Feb

Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition

Experiments in miceBlood and immune system

Paper

Engineered IL-10 variant

Outcomes

Latest

Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition

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