DNA methylation testing

2 papers study it2 findingsUpdated Feb 1, 2026

At a glance

The findings reach people, from one lab or study. 2 independent labs in 1 country.

“could lower the high false-positive rate and find 80% (4/5) missed CIN3+ cases caused by hrHPV testing.”

None of its findings points the other way.

Studies of DNA methylation testing measured one outcome, detection of cervical intraepithelial neoplasia grade 3 or worse.

Detection of cervical intraepithelial neoplasia grade 3 or worse

upin humans1

1 study

DNA methylation testing is linked with better detection of cervical intraepithelial neoplasia grade 3 or worse in humans (Exploratory analysis of cases missed by high-risk HPV testing) (Identified 80% (4/5) of missed CIN3+ cases).
“could lower the high false-positive rate and find 80% (4/5) missed CIN3+ cases caused by hrHPV testing.”
HumansExploratory analysis of cases missed by high-risk HPV testingcervixfemales
The Dual Role of DNA Methylation Test Can Optimize the Clinical Application of High-Risk Human Papillomavirus Testing in Detecting Cervical Intraepithelial Neoplasia Grade 3 or Worse
Journal of medical virologyFeb 1, 2026

Studies link DNA methylation testing with agreement with p16/Ki-67 dual staining.

Agreement with p16/Ki-67 dual staining

mixedin humans1

1 study

DNA methylation testing is associated with agreement with p16/Ki-67 dual staining in humans (HR-HPV-positive women) (Approximately 60% concordant results).
“The two methods showed concordant results in approximately 60% of cases, with the highest concordance observed in women older than 35 years.”
HumansHR-HPV-positive womencervixfemalesn = 44
Methylation test versus dual staining in the triage of HR-HPV positive women - pilot data from cervical cancer screening
Ceska gynekologieJan 1, 2026