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Disturbed sleep

Disturbed sleep has been studied in 3 papers since 2022: 3 observational studies in people. The newest paper, Oct 30, 2024: “Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction”.

Exposure

3 papers study it8 findingsUpdated

See all 3

“People with disturbed sleep have increased risk of hypertension, high cholesterol, and joint pain by more than 80% compared to people with proper sleep.”
Prevalence of Non-Communicable Diseases and Its Associated Factors Among Urban Elderly of Six Indian StatesCureus2022doi:10.7759/cureus.30123

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 2 independent labs in 1 country
  • Funders: National Heart, Lung, and Blood Institute and 5 more
  • 7 of 8 findings with company ties
  • Humans3

What did studies of Disturbed sleep find?

2

Studies of Disturbed sleep measured 2 outcomes; the most studied are frailty (2 studies) and cognitive function (1).

Frailty

upin humans2

2 studies

  1. Disturbed sleep increases frailty in humans (p < 0.01).

    “Worse sleep by SPI and insomnia was associated with worse depression, cognitive function, HRQL, physical disability, health utilities, and Fried Frailty Phenotype frailty (all p < 0.01).”

    Humansin lung transplant recipientsn = 141

    Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction

    JHLT open

  2. Disturbed sleep increases frailty in humans (p<0.01).

    “Worse sleep by SPI and insomnia was associated with worse depression, cognitive function, HRQL, physical disability, health utilities, and Fried Frailty Phenotype frailty (all p<0.01).”

    Humansn = 141

    Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction

    medRxiv : the preprint server for health sciencesPreprint

Cognitive function

downin humans1

1 study

  1. Disturbed sleep impairs cognitive function in humans (p < 0.01).

    “Worse sleep by SPI and insomnia was associated with worse depression, cognitive function, HRQL, physical disability, health utilities, and Fried Frailty Phenotype frailty (all p < 0.01).”

    Humansin lung transplant recipientsn = 141

    Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction

    JHLT open

What is Disturbed sleep linked with?

3

Studies link Disturbed sleep with 3 measures, most often mortality (2 studies), chronic lung allograft dysfunction (2) and hypertension (1).

Mortality

upin humans2HR 1.29

2 studies

  1. Disturbed sleep raises the risk of mortality in humans (HR 1.29, 95% CI 1.05-1.58, p = 0.01).

    “Worsening in SPI but not insomnia was also associated with mortality (HR: 1.29; 95%CI: 1.05-1.58; p = 0.01).”

    Humansin lung transplant recipientsn = 141

    Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction

    JHLT open

  2. Disturbed sleep raises the risk of mortality in humans (HR 1.29, 95% CI 1.05-1.58).

    “Worsening in SPI but not insomnia was also associated with mortality (HR: 1.29; 95%CI: 1.05-1.58; p=0.01).”

    Humansn = 141

    Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction

    medRxiv : the preprint server for health sciencesPreprint

Chronic lung allograft dysfunction

upin humans2HR 2.18

2 studies

  1. Disturbed sleep raises the risk of chronic lung allograft dysfunction in humans (HR 2.18, 95% CI 1.22-3.89, p = 0.01).

    “Those in the worst quartile of SPI and insomnia exhibited an increased risk of CLAD (hazard ratio [HR] 2.18; 95% confidence interval [CI]: 1.22-3.89; p = 0.01 for SPI”

    Humansin lung transplant recipientsn = 141

    Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction

    JHLT open

  2. Disturbed sleep raises the risk of chronic lung allograft dysfunction in humans (HR 2.18, 95% CI 1.22-3.89).

    “Those in the worst quartile of SPI and insomnia exhibited increased risk of CLAD (HR 2.18; 95%CI: 1.22-3.89 ; p=0.01 for SPI”

    Humansworst quartile of SPIn = 141

    Disturbed sleep after lung transplantation is associated with worse patient-reported outcomes and chronic lung allograft dysfunction

    medRxiv : the preprint server for health sciencesPreprint

More on Chronic lung allograft dysfunction

Hypertension

upin humans1

1 study

  1. Disturbed sleep raises the risk of hypertension in humans (>80%).

    “People with disturbed sleep have increased risk of hypertension, high cholesterol, and joint pain by more than 80% compared to people with proper sleep.”

    Humanscompared to people with proper sleep

    Prevalence of Non-Communicable Diseases and Its Associated Factors Among Urban Elderly of Six Indian States

    Cureus

More on Hypertension

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