DESEQ2

1. DESEQ2 improves AUC in silico.

   “DESeq2 consistently demonstrated the best overall performance, showing the highest AUC and AUPRC across all tested conditions.”

   In silicoin scRNA-seq differential gene expression analysis across tested conditions

   Evaluation of statistical differential analysis methods for identification of senescent cells using single-cell transcriptomics

   Cell reports methods·22 Jan 2026

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