Cvd 1926 dleted

1. Cvd 1926 dleted decreases bacterial load in mice.

   “Compared to PBS-immunized mice, mice immunized with CVD 1926 ΔsteD had significantly lower S. Typhimurium counts in the spleen, cecum, and small intestine upon challenge.”

   Animalsspleen, cecum, and small intestine

   Deletion of an immune evasion gene, steD, from a live Salmonella enterica serovar Typhimurium vaccine improves vaccine responses in aged mice

   Frontiers in immunology·Jun 7, 2024

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1. Cvd 1926 dleted increases seroconversion rate in mice (83% vs 42%).

   “After two immunizations, the proportion of seroconverters for CVD 1926 ΔsteD was 83% (10/12) compared to 42% (5/12) for CVD 1926.”

   Animalsn = 12

   Deletion of an immune evasion gene, steD, from a live Salmonella enterica serovar Typhimurium vaccine improves vaccine responses in aged mice

   Frontiers in immunology·Jun 7, 2024

More on Seroconversion rate

1. Cvd 1926 dleted increases FliC-specific CD4+ T cells in mice.

   “Compared to PBS-vaccinated mice, CVD 1926 ΔsteD elicited significantly more FliC-specific CD4+ T cells in the Peyer's Patches.”

   AnimalsPeyer's Patchesn = 12

   Deletion of an immune evasion gene, steD, from a live Salmonella enterica serovar Typhimurium vaccine improves vaccine responses in aged mice

   Frontiers in immunology·Jun 7, 2024

More on FliC-specific CD4+ T cells