Cremophor el

1. Cremophor el shortens lifespan in mice.

   “development of a life-shortening lymphoblastic lymphoma were found in a high frequency in the control group that received Cremophor EL only”

   Animalsfirst lot

   Tenfold increased incidence of spontaneous multiple myeloma in long-term immunosuppressed aging C57BL/KaLwRij mice

   Clinical immunology and immunopathology·May 1, 1996

1. Cremophor el raises the risk of multiple myeloma in mice (6-fold).

   “Repeated experiments with another lot of Cremophor showed a 6-fold increased frequency of NM but no lymphoblastic lymphoma.”

   Animalsvehicle control

   Tenfold increased incidence of spontaneous multiple myeloma in long-term immunosuppressed aging C57BL/KaLwRij mice

   Clinical immunology and immunopathology·May 1, 1996

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