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Combat

Exposure

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development and 5 more
  • In silico1

Outcomes

2

Statistical power and reproducibility

upin humans1

1 study

  1. Combat increases statistical power and reproducibility in humans.

    “simultaneously increasing the power and reproducibility of subsequent statistical analyses.”

    Humansbrain

    Harmonization of cortical thickness measurements across scanners and sites

    NeuroImage17 Nov 2017

Scanner variability

downin humans1

1 study

  1. Combat decreases scanner variability in humans.

    “ComBat removes unwanted sources of scan variability while simultaneously increasing the power and reproducibility of subsequent statistical analyses.”

    Humansbrain

    Harmonization of cortical thickness measurements across scanners and sites

    NeuroImage17 Nov 2017

Funding

5 grants since 2023

Veterans AffairsNational Institute on AgingUS$3.6mEuropean Research Council€150k

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